USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

摘要

Another DUB joins the ranks of deubiquitinating enzymes involved in p53 regulation. USP4 acts on the ubiquitin ligase ARF-BP1/Mule/Huwe1, thus decreasing p53 levels and responses; while senescence ensues in USP4-deficient cells.